this post was submitted on 14 Jan 2025
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Summary

Bryan Johnson, a 46-year-old tech multimillionaire focused on anti-aging, stopped using rapamycin—a supplement he took for five years—after research suggested it might accelerate aging.

Johnson cited side effects like skin infections and glucose issues, as well as findings from a recent study showing rapamycin could worsen epigenetic aging.

Known for extreme anti-aging experiments, Johnson also created the health startup Blueprint, which markets pricey supplements.

His controversial methods, including teenage blood transfusions and genital shock treatments, have raised skepticism about their effectiveness and safety.

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[–] [email protected] 208 points 3 days ago (5 children)

It's an unpopular opinion, but I actually appreciate this guy and what he is doing. He has opted to open his entire research and data to anyone that wants to look at it. So, even though he is definitely a weirdo, the data he is providing might be of some use.

I don't want to look like a vampire, but if his research leads to the discovery of some protein that allows my heart to beat at full strength for a little longer, or slows down the onset of dementia, etc., then I'm all for him wasting his money trying to look like a Twilight cast member.

[–] [email protected] 127 points 3 days ago (1 children)

I like that he's willing to really fuck up his own body to see what happens. I don’t like that he's peddling supplements.

[–] [email protected] 51 points 3 days ago

Notice I used the word "appreciate" instead of "like".

[–] livjq 60 points 3 days ago (2 children)

But he's involving so many variables, is his data even useful? I don't understand how you could extrapolate anything from a guy who takes so many supplements that may cause conflicting outcomes.

[–] [email protected] 44 points 3 days ago (3 children)

Someone who has a background in science would know that testing on a single person is not very useful for what other posters are wishing for (new proteins, new anti aging treatments).

This billionaire has age dysmorphia and is using his wealth to experiment around. It’s unfortunate really.

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[–] [email protected] 55 points 3 days ago (3 children)

This isn't real research ... it's just a millionaire spending money on trying to live longer for themselves while selling and marketing products on the side.

If it were real research, it would involve a group of recognized researchers and scientists testing products and activities on a small group of volunteers who are fully aware of what they are participating in. And the research has to last for several years using multiple controls.

Watching one guy testing and trying out a few things whenever he feels like it and done at his own whim and under only his opinion and likes and dislikes is not research.

The biggest contribution he has to longevity is in promoting and advertising the fact that one of the ways to extend your lifespan is to become a millionaire.

[–] [email protected] 19 points 2 days ago

Someone testing on themselves is how we learned what causes and how to treat ulcers (the researcher earned a Nobel prize for giving himself an ulcer, and then treating it), among other things.

Controlled trials are great, but research has to start somewhere.

[–] Zombiepirate 18 points 3 days ago (1 children)

You're telling me that shocking one's nards on a hunch and writing it down isn't real research?

I'm starting to think I know nothing about science. What have I been doing?

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[–] trashgirlfriend 6 points 2 days ago* (last edited 2 days ago)

It's one guy who is going through like a million treatments.

It's cool that the data is available but what helpful information can be gained from it other than "what happens if you do jackass but healthy?"

[–] [email protected] 13 points 3 days ago (1 children)

A sample size of one is pretty much useless. The only good thing to come out of his work is the publicity and public interest in anti aging imo.

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[–] Allonzee 60 points 3 days ago (1 children)
[–] [email protected] 4 points 2 days ago (1 children)

I just watched this movie again today, wasn’t expecting a meme of it so quickly!

[–] Allonzee 2 points 2 days ago (1 children)

I know it's not the popular choice, but Last Crusade is by far my favorite of the Franchise. I re-watch it way more than Raiders.

[–] [email protected] 2 points 2 days ago

Ditto, I think it’s the best out of all of them!

[–] [email protected] 32 points 2 days ago (4 children)

"genital shock treatments"

Ok..... how did someone sell that as an anti-aging treatment?

[–] Uruanna 19 points 2 days ago (1 children)

The salesman: "anti-what?"

[–] [email protected] 7 points 2 days ago

The passing of time must be stored in the balls.

[–] Jumpingspiderman 3 points 2 days ago

My guess would be Uncle Rico from Napoleon Dynamite.

[–] aesthelete 10 points 2 days ago

I don't usually like salespeople, but this one I like a lot.

[–] 5too 3 points 2 days ago

I'm choosing to read that as someone is screwing with him.

[–] iAvicenna 14 points 2 days ago* (last edited 2 days ago) (1 children)

Is this the trickle down economics everyone is talking about? shall we again start selling uranium, platinum etc beverages to the rich?

He has a team for this?

“Despite the immense potential from pre-clinical trials, my team and I came to the conclusion..."

Forget trickle down economics, this is insane just bring the guillotines.

[–] [email protected] 2 points 2 days ago

It's so completely unfair that idiots like this guy make millions of snake oil "experiments" that don't even work, but people who dedicate all their time and energy into a labor of love are left to rot

[–] [email protected] 36 points 3 days ago (2 children)

Watched the documentary with a friend; we were trying to guess his age. We agreed on "decent looking for 55". He's 47 lol.

[–] ameancow 23 points 3 days ago* (last edited 3 days ago)

People who are obsessed with some physical quality about themselves always make whatever the issue is, like 1000% worse than if they just left it alone and lived normally.

[–] Buddahriffic 12 points 3 days ago (1 children)

His face looks old enough to make his hair look unnatural.

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[–] BigBenis 17 points 2 days ago (1 children)

This guy looks like he's 60 cosplaying as a 20 year old

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[–] yrnttm 19 points 2 days ago (4 children)

This dude is just going to spend a bunch of money on shit that will eventually kill him. What a waste.

[–] aesthelete 6 points 2 days ago

What an efficient allocation of capital!

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[–] dhork 42 points 3 days ago

Hah, sounds like his "research" is trying it out on himself and deciding he didn't like it. And now that he doesn't like it, all of a sudden he finds the research valid. He's still only listening to opinions he agrees with. What a shallow twat.

[–] Aqarius 10 points 2 days ago (1 children)

I see the proud tradition of drinking mercury concoctions is alive and well. I mean, not well, but...

[–] roguetrick 2 points 2 days ago

Would be nice if the dude just went ahead and dove into taoist alchemy instead of trying to create a veneer of actual science.

[–] givesomefucks 34 points 3 days ago (3 children)

Rapamycin

It's not just "one of many" it was the big one that has a large online following swearing by it, and lots of idiots taking it.

Also I can't see a pic of this guy without thinking of Dennis Reynolds asking if he should wear a mask of his own face.

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[–] [email protected] 20 points 3 days ago

I bet I live longer than him, and on a shoestring budget

[–] Fedizen 27 points 3 days ago (1 children)

this guy sucks. He's conducting essentially a thousand uncontrolled trials on himself making them all useless unless he dies of a new contraindiction

[–] [email protected] 16 points 3 days ago (3 children)

Why does he suck though? Aren't we all conducting uncontrolled trials on ourselves? Better that, than doing it on other people, right?

[–] Fedizen 0 points 1 day ago

He's doing what all of us are doing which is why the whole article is just ego fellatio for a rich dullard.

[–] NotMyOldRedditName 13 points 3 days ago* (last edited 3 days ago) (2 children)

I think what they meant is even if he finds something that works, the data can't be trusted, which will heavily delay things like doing it properly.

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[–] [email protected] 25 points 3 days ago (1 children)

I watched his video describing a day in his life, sleep at 8pm and wake up at 5am, then take 50 pills, his whole day revolved around preparing for sleep, which he said was the most important thing, so I guess he's right about that. But just thinking a tiny change in his life, even travelling, will upset this routine, then what, the stress from that routine is probably aging him the most.

[–] quixotic120 16 points 3 days ago* (last edited 3 days ago) (1 children)

That’s the thing, he might live a bit longer but at what cost? I would much rather enjoy my life than by a slave to a miserable routine dedicated to promoting longevity that will potentially buy me an extra decade. Like I can just eat a somewhat reasonable diet, exercise, sleep okay and with decent genetics based on my parents and grandparents I will probably make it to at least mid to late 80s, maybe longer if medicine advances. If I had genetics that suggested a strong likelihood that I would die in my 60s I would maybe be more interested

With this guys routine I could maybe push that to 100ish? I would certainly love to extend my life but not at the cost of it consuming my life. I assume he’s banking on getting to the theoretical max though, which is probably closer to 120ish, and that is substantial but then it’s like a few decades of extremely decreased mobility and mental acuity? Eh

And of course this all disregards the potential that you get cancer, murdered, car accident, etc.

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[–] jaybone 17 points 3 days ago

Had to check this wasn’t nottheonion

[–] Scott_of_the_Arctic 17 points 3 days ago

The guy looks like one of those Kraftwerk robots.

[–] teft 22 points 3 days ago (3 children)

I'm in my forties and he doesn't look noticeably younger than I do except for my hair being salt and pepper. I don't look exceptionally young or anything, it just doesn't seem like his regimen is really doing anything that diet, exercise, and sunscreen can't also accomplish.

[–] kamenlady 19 points 3 days ago

I can imagine that having a hyperfocus on anti-aging and unstoppably aging at the same time, must be really stressful and at the end of the day, ends up contributing to a faster aging overall.

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[–] Mediocre_Bard 8 points 2 days ago (5 children)

It would be hilarious if the societal collapse caused by wealth inequality resulted in him getting murdered. I would laugh and laugh.

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[–] apfelwoiSchoppen 18 points 3 days ago (2 children)

The Dennis System for Aging

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[–] [email protected] 14 points 3 days ago (4 children)

When you’ve got everything in life and all you want to do is live longer.

instead of helping the billions living in squalor and dying premature deaths.

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[–] motor_spirit 15 points 3 days ago

Lmao the picture of this dude is like Paul Rudd on Star Trek

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