this post was submitted on 02 Oct 2024
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[–] [email protected] 3 points 3 months ago

They get destroyed by stomach acids and saliva enzymes. Unlikely to even make it towards First pass.

[–] InverseParallax 2 points 3 months ago

First pass metabolism, or just absorbed by mucous membranes of the mouth, blood flow isn't great so absorption is less systemic, just mess up your mouth and throat a bit really, but might help some symptoms locally.

The nasal dose is low compared to oral and those dissolve in areas with high blood uptake.