The letter comes as polling within the Muslim American community shows a major departure from the Democratic Party over the Biden-Harris administration's unfettered support for Israel's war on Gaza, which they along with rights groups and legal experts view is a genocide against Palestinians.
The letter calls on Muslims to instead vote for any of the third-party candidates, including the Green Party's Jill Stein whose support has swelled among the Muslim American community in recent weeks.
"We want to be absolutely clear: don’t stay home and skip voting. This year, make a statement by voting third party for the presidential ticket," the letter said.
"Equally important, vote all the way down the ballot for candidates and policies that stand for truth and justice, ensuring your voice is heard at every level."
The letter, written and released in collaboration with the Abandon Harris campaign, was signed by more than three dozen religious leaders from all around the country, including Dawud Walid, Dr Shadee Elmasry, Imam Omar Suleiman, Dr Yasir Qadhi, and Imam Tom Facchine.
The imams who have signed the letter say the calls for Muslims to uncritically support Harris is fear-mongering.
"None of this is an endorsement of Donald Trump's vile, racist agenda, which includes advancing the apartheid and genocidal interests of a foreign state while falsely claiming to put America first," the letter said.