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So imma explain some shit maybe poorly with what’s been happening in the psychiatric world.
Recently some huge studies have been published showing that what’s really going on in depression or anxiety isn’t neurotransmitter related it’s synapse related. Let me explain. As you go from being a baby to being 25 years old your brain goes from roughly 200M neurons to 100M neurons. Tf how do you not get stupider?? Well bitches it’s because of something called synaptic pruning. This reinforces the good synapses and eliminates useless synapses/neurons. Okay with all that being said for every neuron in your brain you have ~1000 synapses if you’re healthy. In depression or anxiety you have ~500. So they’ve found by stimulating synapses regeneration you can effectively treat depression from its root biological cause. A drug called Auvelity which is extremely new does this and it’s fucking amazingly effective. I’m talking like a week until you’re feeling better.
Now with all that being said, I’m betting the reason these psychedelics work as treatment is because they stimulate axonal regeneration. But they have the side effect of tripping tf out which can backfire and cause retraumatization.
I hope this makes sense or is cool to others, because it’s fucking awesome to me. Tons of people are about to get waaaaay better mentally because of this research.
Just to add to your point: in PTSD your brain will prioritize certain synapses over others that may help you survive through the trauma, but will result in a continued focus on the trauma after the event has passed. So those ~500 synapses in depressive PTSD aren't just lower than a healthy brain, but they're also the wrong synapses for your current situation. Psychedelics can help you develop new synapses that are more relevant to your current life. As someone who experienced this therapy, it's amazing how quickly it can happen, too. It's a total game changer and should be available to anyone who wants to try it.
😮 I want to believe your explanation, but it sounds too good to be true.
It’s very true. I’ve been seeing people get these drug samples for Auvelity (because it’s expensive af right now being so new and all) and they get much better in a week and then sooooo much better after 2 months that you can take them off Auvelity. I’m super excited for everyone to get better
Yeah mate its cool to me nice info
So all these years of rampant drug abuse have been good for me? Take THAT stupid school drug training.
Well written post, thanks.
Depression doesn't have one cause.
And MDMA and other forms of psychedelic treatment are more about the cultural factors than the chemistry. I.e. the ritual space we create around it. In this case, the therapeutic safe space where someone can unpack without tripping the fuck out as you put it.
Not discounting the medicine you're taking, but please don't discount psychedelics just because you started taking cough syrup and Wellbutrin (DXM is the main ingredient in cough syrup).
Additionally, Auvelity, as I just eluded too, isn't a new game changing drug. It's a mix of two older drugs. An SNRI/Dissasociative (mostly SNRI because the Wellbutrin keeps it from metabolising into it's fun form) and a DNRI. In other words, you're on every form of reuptake inhibitor we use to treat depression. One that slows your liver down (meaning you wiill have side effects if you take any other drug processed through this pathway) and gets you a little disassociated, like a very small bit of ketamine.
That's what you're taking. I don't know anything about neural pruning. I guess you're talking about the need for neurogenesis to change patterns of feeling. Ketamamine (and DXM) do do this, but so do classic psychedelics.
And what new patterns you form, are going to depend on set and setting (mindset and environmental context). DXM/Wellbutrin can change part of the equation. Psychedelic therapy looks at both.
I’m not taking it I’ve seen patients take it and report how effective it is. It’s a new game changing drug combo great that we have to be picky about words. I’m confident that this is the new sertraline where everyone will be prescribed this in a few years. I learned how this drug works from a very high accolade psychiatrist so I trust him on it. And as I said at the end of my post I’m pretty sure neurogenesis is the reason these psychedelics work, but people aren’t fast tracking them because of potential for abuse and for potential of retraumatisation or worsening of other symptoms. So I’m not bashing psychedelics, just trying to offer to people a possible explanation for why these recreational drugs are working
DXM is way more abusuable than psychedelics. And, as I said, Wellbutrin is a serious liver enzyme inhibitor that won't allow you to take any drug processed through that pathway without serious side effects.
The drug combination works by shutting down one of DXMs metabolic pathways. But because it has two, instead of causing you to overdose, it just doesn't metabolize into DXO (a much stronger disassociative).
And both chemicals cause physical withdrawal. And, DXM itself can be addictive in a psychological sense.
I understand the hype, DXM is a fascinating compound and this is an interesting way to use it. But the drug does have serious side effects and tons of drug interactions because of the liver enzyme inhibition.
I don't think it's the magic bullet the pharmaicutical industry pretends it is. And having tried it myself, it wasn't a game changer but rather made me feel like shit and made me paranoid to put any other compound in my body.