this post was submitted on 20 Mar 2024
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Ive been on opioids a couple of times for dental related issues and never got addicted. These people are just weak, and I don’t really mind that a nurse got some extra money for giving them something they’d rob and steal for anyway. 20 years is a harsh sentence
This may un-ironically be the worst lemmy comment I've seen since joining.
Congrats, you absolute nonce.
You took pain medicine for dental related issues? Sounds like you're the one who is weak. My teeth don't hurt at all.
You’re really gatekeeping addiction? News flash, just because you find it so easy and simple doesn’t invalidate the struggle that millions of other addicts in the world suffer. These opiate pushers are enablers that take advantage of people in need.
Nope.
Just human variation.
I've been prescribed opioids before, and they legit do nothing for me. Because I'm lacking a liver enzyme that breaks it down into active elements and to use those active elements.
Sounds like you do as well
Some people are the other way, they have too much of that enzyme and "burn through" a pill faster than average.
So they get overdosed at first, then it wears off hours before the next pill, opening the door to abuse.
Opioid manufacturers knew all about this, but still pushed time release pills because they had a higher profit margin.
Which is why they've been sued for billions of dollars
could you find a link please like to read more about this
https://www.mayoclinicproceedings.org/article/S0025-6196%2811%2960750-7/fulltext
That's a general article about opiod metabolism and what causes it to vary. So it talks about what I had said but also some other reasons people are effected differently like liver/kidney disease.
When companies started pushing extended release, it greatly exacerbated the differences. They knew that from research, but pushed doctors to try it as the first step.
Edit:
Side note, that article also shows what liver enzyme metobalizes certain opioids.
A huge example is Fentanyl using a different one from Oxycodone and other common opioids.
So not only is it dangerous because of its dosage amounts, someone that believes they have a strong opioid tolerance due to abuse might be a fast CYP3A4 metabolizer. So just the tiniest but of Fen could make them OD.
All this shit is way more complicated than most people ever realize.
I took a class on pharmaceuticals and the professor started every class by saying:
Anything that deals with hormones, neurotransmitters, or metabolism is going to react differently, even if most fall into a normal distribution, there's always outliers.
We really should have started normalizing genetic testing and tailoring treatment to individuals decades ago.
This shit isn't expensive and avoids a lot of trial and error that could cause serious complications not to mention wasted time.
Gotta be a troll.... This take is far too stupid to be real...