this post was submitted on 20 Mar 2024
76 points (100.0% liked)
Health - Resources and discussion for everything health-related
2389 readers
328 users here now
Health: physical and mental, individual and public.
Discussions, issues, resources, news, everything.
See the pinned post for a long list of other communities dedicated to health or specific diagnoses. The list is continuously updated.
Nothing here shall be taken as medical or any other kind of professional advice.
Commercial advertising is considered spam and not allowed. If you're not sure, contact mods to ask beforehand.
Linked videos without original description context by OP to initiate healthy, constructive discussions will be removed.
Regular rules of lemmy.world apply. Be civil.
founded 2 years ago
MODERATORS
you are viewing a single comment's thread
view the rest of the comments
view the rest of the comments
https://www.mayoclinicproceedings.org/article/S0025-6196%2811%2960750-7/fulltext
That's a general article about opiod metabolism and what causes it to vary. So it talks about what I had said but also some other reasons people are effected differently like liver/kidney disease.
When companies started pushing extended release, it greatly exacerbated the differences. They knew that from research, but pushed doctors to try it as the first step.
Edit:
Side note, that article also shows what liver enzyme metobalizes certain opioids.
A huge example is Fentanyl using a different one from Oxycodone and other common opioids.
So not only is it dangerous because of its dosage amounts, someone that believes they have a strong opioid tolerance due to abuse might be a fast CYP3A4 metabolizer. So just the tiniest but of Fen could make them OD.
All this shit is way more complicated than most people ever realize.
I took a class on pharmaceuticals and the professor started every class by saying:
Anything that deals with hormones, neurotransmitters, or metabolism is going to react differently, even if most fall into a normal distribution, there's always outliers.
We really should have started normalizing genetic testing and tailoring treatment to individuals decades ago.
This shit isn't expensive and avoids a lot of trial and error that could cause serious complications not to mention wasted time.