A lot of the worst experiences I've were trying to run games to get friends into it, doubly so because I have so little practical experience running a game beyond reading books and copying from them thinking I'm about to have fun, and none actually playing beyond what I described.

I've explored alternate systems such as GURPS and tried brewing a few of my own. I can criticize the rules all day but at the end it was always much the same experience trying to run those against a group that intentionally spites any prep (usually geared more toward worldbuilding and important NPCs than any specific story arc, I realize you can't force that stuff) I tried to do. Anything that I had a sheet of paper for, they would turn and walk away every single time.

As for setting... fam there's not a lot I can do when everyone i know who plays only ever wants to play vanilla DnD or their take on MtG flavored DnD, and they're not going to change what they're doing just because I'm sick to death of generic corporate fantasy worlds and waiting around for 9/10 of the time we're at the table.