In April 2019, a Twitter post by Pyle from 2017 resurfaced regarding the pro-life rally March For Life. According to some reporters, Pyle's tweet expressed support for, or defended, March For Life. The tweet caused many fans to turn against Strange Planet and its creator, in a controversy described by at least one outlet as an example of the Milkshake Duck phenomenon.[23][24][25]

Pyle released a statement shortly afterwards which did not mention abortion, but said that he and his wife "have private beliefs as they pertain to our Christian faith. We believe separation of church and state is crucial to our nation flourishing." He also stated they voted for the Democratic Party, and were "troubled by what the Republican Party has become and [did] not want to be associated with it."[25][26][27]

In 2022, he posted to social media in support of Bernie Sanders' tweet in response to the overturning of Roe v. Wade, which called the decision "an outrage" and supported codifying Roe into law.[28]