this post was submitted on 03 Aug 2023
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[–] [email protected] 30 points 1 year ago

This is the best summary I could come up with:


A "cancer-killing pill" has appeared to "annihilate" solid tumours in early research - leaving healthy cells unaffected.

Professor Linda Malkas, who has been developing the drug, explained: "PCNA is like a major airline terminal hub containing multiple plane gates.

"Our cancer-killing pill is like a snowstorm that closes a key airline hub, shutting down all flights in and out only in planes carrying cancer cells."

While initial results are promising, the research so far has only concluded that AOH1996 can suppress tumour growth in cell and animal models - with the first phase of a clinical trial in humans now under way.

The pill has been shown to be effective in treating cells derived from breast, prostate, brain, ovarian, cervical, skin and lung cancers.

PCNA had previously been labelled as "undruggable" - and it is hoped the breakthrough could lead to more personalised, targeted medicines for cancer in the future.


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[–] [email protected] 23 points 1 year ago (5 children)

Looks like a treatment, not a cure, that will require ongoing supplies of medication. This is a pharma wet dream. We can’t cure your cancer, but we can keep it from growing for just $2000 per pill that cost us $1 to make.

[–] Neuraxis 21 points 1 year ago* (last edited 1 year ago) (2 children)

Do you really think that pill cost 1$? A single approved therapy takes years to develop and over a billion dollars. But hey if you're view of an entire industry is shaped through Facebook comments I don't blame you.

Further, maintenance therapy already exists in many cancers. This is not a new concept for literally anyone in the field of medicine.

[–] unused_nerons 34 points 1 year ago (3 children)

You speak like someone whose never had to buy insulin before.

[–] sznowicki 35 points 1 year ago (1 children)

Which is cheap or free in literally everywhere except the country of free. It’s US problem, not industry.

[–] [email protected] 8 points 1 year ago (2 children)

I'm from a country in western Europe, and our pharmacies are running low. My dad was told several times over the last months that they're out of stock and he should come back next week. Sure, the price here might be okay, but Pharma seems to prefer selling it more expensively elsewhere.

[–] [email protected] 7 points 1 year ago

I live in the US, my wife couldn't find test strips for over a week.

[–] hackitfast 6 points 1 year ago

They're probably creating artificial scarcity to increase the prices elsewhere on account of "supply and demand". There's a special place in hell for them.

[–] [email protected] 3 points 1 year ago (1 children)

Insulin is worse though because it’s not like it’s a drug that had to be developed and has a billion dollars or more to develop. The case with insulin is blatant price gouging.

This pill, this doesn’t mean it should be as cheap as insulin as the two drugs aren’t equals. It can be priced fairly and still be expensive, we don’t know the economics behind it. Being cheap =/= fair pricing all the time. Like buying a better product that took more to make.

This could still be outrageously priced obviously, but comparing it to insulin is apples to oranges.

[–] Carighan 2 points 1 year ago (1 children)

You are doing exactly the thing the person you are replying to is calling someone out for, so if anything you are underlining the point. Pharmaceuticals is a vast industry, and the matter they work with is not homogenous.

You cannot infer from the cost of insulin to inhabitants of uncivilized western countries what the actual cost of providing a still in-development medicine will be. More specifically, you cannot expand from being ripped off in one country for one medicine and the myopic view that provides to pharmaceuticals as a whole.

As a counterpoint in your case, I pay nothing for my insulin, as its included the base medical insurance everyone has to have. As are a vast amount of other pharmaceuticals.

[–] unused_nerons 5 points 1 year ago (2 children)

I gave an example of a treatment style pharmaceutical that has been used consistently to boost corporate profits rather than serve the greater good. Would you like to talk about the cost of epipens next? How about the opioid industry?

[–] [email protected] 7 points 1 year ago (1 children)

A pill that treats solid tumours would be an enormous boon to humanity. You're letting really tired cynicism get in the way of basic logic. This argument would mean that insulin wasn't a breakthrough, because it didn't cure diabetes.

For profit pharmaceuticals is indeed a huge issue, but it's one that is entirely separate from whether or not a given medical treatment is good or not.

[–] [email protected] 2 points 1 year ago

grumble grumble Look at this big pharma scheme that allows people to live longer! grrrr I'd rather die from cancer than let big pharma take my hard-earned dollars!

[–] [email protected] 4 points 1 year ago (1 children)

Are you saying insulin has not served the greater good? This whole "treatments are a conspiracy to enrich corporate profits" BS is crazy. That it can happen, and sometimes does happen, does not mean it always happens or never happens.

The world is complicated. Simplified "pharma bad" arguments are pure fantasy.

[–] Carighan 3 points 1 year ago

Not only that, it's also important to consider just how vast pharmaceuticals as a branch of industry and research and medicine is, overall.

Sure, some exec at the top might be a money-grubbing arsehole who couldn't care any less if 8 billion people died so long as they made 2% more profits.

But there's a giant apparatus of often very serious and very altruistic researchers, doctors, nurses, workers and helpers underneath that, too. Lots of bad apples, lots of shining examples. Just like, well, any other industry.

And sure, one can easily argue "but you're playing with people's lives here, it's not okay for it to be like this". And of course I agree. But it's utopian to think we can fix this with reductive, as you say, "pharma bad"-arguments. And it's not like the transport industry, the power industry, the the military-industrial complex (intentionally) or the tourism industry don't habiutally play with people's lives. We just tend to not notice it as directly.

And sure, I get that for americans in particular this is a sore topic of particular import because they're so vulnerable to exploitation due to a lack of social support structure and regulated and standardized insurances.

But anything can be reduced to a simple "is bad" if we want it to. It's important to not think in such simplistic us-vs-them terms, otherwise nothing can ever be improved.

[–] [email protected] 13 points 1 year ago (1 children)

No I don’t think it will cost a dollar. That was hyperbole.

[–] [email protected] -3 points 1 year ago* (last edited 1 year ago) (2 children)

That's what it is, a subscription based cure.

"as long as you buy our medicine you will live!"

I sure hope it isn't like this. Medicine just enough to stave the progress of the illness but also not enough to cure it.

[–] Carighan 3 points 1 year ago (1 children)

I find it a bit reductive to call palliative care a moneymaking scheme overall. Especially cruel to workers in the field, which is one of the toughest one as far as mental health goes.

[–] [email protected] 3 points 1 year ago* (last edited 1 year ago)

Yeah I do understand what you are saying. And I may have gone too overboard with my pessimism. This being cancer and all.

It's just that too many bad actors have taken advantage of regular folks and their situations. It's hard not to react in a pessimistic view when there's hardly any good news to come by, or any good development that gets twisted into a nightmare of a tool just to take advantage of people's hope for better care.

[–] [email protected] 0 points 1 year ago (1 children)

I know what you're saying, but cancer being a chronic condition is great.

[–] [email protected] 1 points 1 year ago

I agree. Would I rather have no cancer? Absolutely. But if my body is going to crank up some cancer cells anyway, I’d rather have chronic (but managed) cancer and keep living than just cancer that will kill me.

[–] [email protected] 14 points 1 year ago

At the moment, it doesn’t look like anything, since it’s just now in phase 1 trials, so nobody knows.

But if it does what it says, then yes, it might actually be part of a cure.

And I don’t know if you’re aware of it, as of now we don’t have a cure for cancer: https://xkcd.com/931/

You can look up the average treatment cost today, it’s something like $150000, good for your that you already know the price of this pill and that it’s big pharma‘s wet dream.

[–] [email protected] 12 points 1 year ago

"Why don't they just cure cancer!"

🙄

[–] [email protected] 16 points 1 year ago

Heard about this on the radio yesterday, and looked into it further as we hear about “cancer curing pills” all the time and they usually are nothing. This one does seem to have traction however IF it can make it through human trials. So obviously could mean nothing if it doesn’t pass this phase, and it will be there a long time, but this is very promising news.

[–] xc2215x 13 points 1 year ago

Good to see this pill be created. Very nice.

[–] [email protected] 1 points 1 year ago (1 children)
[–] [email protected] 2 points 1 year ago

I just created the summary! You can find it at https://lemmings.world/comment/894209. (I tried to create the link for your instance but I failed miserably, for which I'm very sorry).

[–] Fedizen -5 points 1 year ago (1 children)

Joe Brandon filling his campaign promise /s

But it is good to see more treatment options

[–] Burn_The_Right 7 points 1 year ago* (last edited 1 year ago) (1 children)

Maybe conservatives will treat this medical advancement the same as other medical advancements. To be fair, these pills are obviously loaded with 5G tracking chips and are clearly not as effective against cancer as horse dewormer or bleach.

[–] june 7 points 1 year ago (1 children)

It’s funny how my mom has no issue at all with everything they load her up with for her cancer, but vaccines? That’s a bridge too far.