this post was submitted on 25 Dec 2023
292 points (89.7% liked)

News

23407 readers
5416 users here now

Welcome to the News community!

Rules:

1. Be civil


Attack the argument, not the person. No racism/sexism/bigotry. Good faith argumentation only. This includes accusing another user of being a bot or paid actor. Trolling is uncivil and is grounds for removal and/or a community ban. Do not respond to rule-breaking content; report it and move on.


2. All posts should contain a source (url) that is as reliable and unbiased as possible and must only contain one link.


Obvious right or left wing sources will be removed at the mods discretion. We have an actively updated blocklist, which you can see here: https://lemmy.world/post/2246130 if you feel like any website is missing, contact the mods. Supporting links can be added in comments or posted seperately but not to the post body.


3. No bots, spam or self-promotion.


Only approved bots, which follow the guidelines for bots set by the instance, are allowed.


4. Post titles should be the same as the article used as source.


Posts which titles don’t match the source won’t be removed, but the autoMod will notify you, and if your title misrepresents the original article, the post will be deleted. If the site changed their headline, the bot might still contact you, just ignore it, we won’t delete your post.


5. Only recent news is allowed.


Posts must be news from the most recent 30 days.


6. All posts must be news articles.


No opinion pieces, Listicles, editorials or celebrity gossip is allowed. All posts will be judged on a case-by-case basis.


7. No duplicate posts.


If a source you used was already posted by someone else, the autoMod will leave a message. Please remove your post if the autoMod is correct. If the post that matches your post is very old, we refer you to rule 5.


8. Misinformation is prohibited.


Misinformation / propaganda is strictly prohibited. Any comment or post containing or linking to misinformation will be removed. If you feel that your post has been removed in error, credible sources must be provided.


9. No link shorteners.


The auto mod will contact you if a link shortener is detected, please delete your post if they are right.


10. Don't copy entire article in your post body


For copyright reasons, you are not allowed to copy an entire article into your post body. This is an instance wide rule, that is strictly enforced in this community.

founded 1 year ago
MODERATORS
you are viewing a single comment's thread
view the rest of the comments
[–] smooth_tea 8 points 11 months ago (2 children)

The article actually states how much. 15% of the daily recommended amount.

[–] [email protected] 6 points 11 months ago (2 children)

There's a daily recommended amount for mice? Or was that 15% of the recommended amount for humans, which would be massive for mice?

[–] [email protected] 1 points 11 months ago (2 children)

15% of humans recommended amount. It's in the article.

[–] smooth_tea 3 points 11 months ago (1 children)

Actually no, the keyword is equivalent, so adjusted for body weight.

[–] [email protected] 2 points 11 months ago

Ah I think you're right.

[–] [email protected] 0 points 11 months ago (1 children)

So 15% for a 60 kilogram human, on the lower end, would be the daily recommended amount for a 9 kilogram creature. A mouse weighs around 0.025 kilograms. So, that amount for the mice is for something 360 times larger.

Obviously it's more complicated than that with differing metabolisms and the like, but as a rough estimate, wow. That's a lot.

[–] smooth_tea 2 points 11 months ago

I'm baffled by your willingness to elaborate at length about this, but not read the article where this is explained. Misinforming everyone in the process.

When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA's recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.

[–] smooth_tea 1 points 11 months ago

It's the equivalent of the human daily dose. So adjusted for body weight. Loosely translated, it would be 15% of the daily recommended dose for mice.

[–] capt_wolf 3 points 11 months ago (1 children)

I stand corrected! That's a ridiculously small amount!

[–] [email protected] 0 points 11 months ago (2 children)

Just in case you missed it, we discussed below that that's the 15% daily recommended amount for a human. That they gave to the mice. A creature several hundred times smaller.

So you were right in the first place.

[–] smooth_tea 4 points 11 months ago

No, it's the equivalent dose.

When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA's recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.

[–] [email protected] 1 points 11 months ago

Can you cite your sources? This excerpt from the published article suggests you're wrong:

The FDA recommended maximum DIV for aspartame for humans is 50 mg/kg (33). Based on allometric conversion utilizing pharmacokinetic and body surface area parameters (43), the mouse equivalent of the human DIV is 615 mg/kg/d. Therefore, the male mice received a daily aspartame dose equivalent to 14.0%, 7.0%, and 3.5% of the FDA recommended human DIV, and the females received a dose equivalent to 15.5%, 7.7%, and 3.9% of the human DIV.