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A Popular Sweetener Was Linked to Increased Anxiety in Generations of Mice (www.sciencealert.com)

submitted 8 months ago by [email protected] to c/news

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[–] capt_wolf 5 points 8 months ago* (last edited 8 months ago) (1 children)

Guarantee the study also states that you have to consume an ungodly amount of it too...

News reports grab on to stuff like this all the time. Like what they did with safrole.

[–] smooth_tea 8 points 8 months ago (2 children)

The article actually states how much. 15% of the daily recommended amount.

[–] [email protected] 6 points 8 months ago (2 children)

There's a daily recommended amount for mice? Or was that 15% of the recommended amount for humans, which would be massive for mice?

[–] [email protected] 1 points 8 months ago (2 children)

15% of humans recommended amount. It's in the article.

[–] smooth_tea 3 points 8 months ago (1 children)

Actually no, the keyword is equivalent, so adjusted for body weight.

[–] [email protected] 2 points 8 months ago

Ah I think you're right.

[–] [email protected] 0 points 8 months ago (1 children)

So 15% for a 60 kilogram human, on the lower end, would be the daily recommended amount for a 9 kilogram creature. A mouse weighs around 0.025 kilograms. So, that amount for the mice is for something 360 times larger.

Obviously it's more complicated than that with differing metabolisms and the like, but as a rough estimate, wow. That's a lot.

[–] smooth_tea 2 points 8 months ago

I'm baffled by your willingness to elaborate at length about this, but not read the article where this is explained. Misinforming everyone in the process.

When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA's recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.

[–] smooth_tea 1 points 8 months ago

It's the equivalent of the human daily dose. So adjusted for body weight. Loosely translated, it would be 15% of the daily recommended dose for mice.

[–] capt_wolf 3 points 8 months ago (1 children)

I stand corrected! That's a ridiculously small amount!

[–] [email protected] 0 points 8 months ago (2 children)

Just in case you missed it, we discussed below that that's the 15% daily recommended amount for a human. That they gave to the mice. A creature several hundred times smaller.

So you were right in the first place.

[–] smooth_tea 4 points 8 months ago

No, it's the equivalent dose.

When a sample of mice were given free access to water dosed with aspartame equivalent to 15 percent of the FDA's recommended maximum daily amount for humans, they generally displayed more anxious behavior in specially designed mood tests.

[–] [email protected] 1 points 8 months ago

Can you cite your sources? This excerpt from the published article suggests you're wrong:

The FDA recommended maximum DIV for aspartame for humans is 50 mg/kg (33). Based on allometric conversion utilizing pharmacokinetic and body surface area parameters (43), the mouse equivalent of the human DIV is 615 mg/kg/d. Therefore, the male mice received a daily aspartame dose equivalent to 14.0%, 7.0%, and 3.5% of the FDA recommended human DIV, and the females received a dose equivalent to 15.5%, 7.7%, and 3.9% of the human DIV.