Bots:
Pummeler, that one heavy pistol that isn't the senator, stun grenades, heavy Armor with extra grenades or peak physique, AMR, ballistic shield, stun mortar, OPS
Bugs:
Pummeler, grenade pistol, stun grenades, light or heavy Armor with extra nades, flamethrower, Gatling turret, OPS, eagle airstrike.
Against bots, pummeler and ballistic shield makes you basically invincible. Against bugs, I've found heavy Armor to drastically outperform light Armor. You don't need speed if nothing really damages you.
As someone who never used an immutable distro: what are the quirks when using it?