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Multiple case reports have shown that continuous exposure to silica increases the risk of positive ANCA.

Studies have confirmed the dose-related effects of silica exposure. A meta-analysis showed that silica exposure was positively associated with AAV. A case-control study suggested a 3.4-fold increased risk of ANCA serology positivity in individuals with occupational silica exposure.

Another study suggested that silica can induce the expression of MPO in the cell membrane of neutrophils and monocytes, causing ANCA-related autoimmune responses.

However, research on the relationship between sustained exposure to silica and severity of AAV remains inadequate.

Multiple case reports have shown that continuous exposure to silica increases the risk of positive ANCA.

Studies have confirmed the dose-related effects of silica exposure. A meta-analysis showed that silica exposure was positively associated with AAV. A case-control study suggested a 3.4-fold increased risk of ANCA serology positivity in individuals with occupational silica exposure.

Another study suggested that silica can induce the expression of MPO in the cell membrane of neutrophils and monocytes, causing ANCA-related autoimmune responses.

However, research on the relationship between sustained exposure to silica and severity of AAV remains inadequate.

Multiple case reports have shown that sustained exposure to silica in an occupational environment resulted in a significantly increased risk of ANCA positivity.

A meta-analysis involving six case-control studies showed that silica exposure was positively associated with AAV incidence.

Additionally, exposure to air pollutants, such as carbon monoxide (CO), is a risk factor for AAV.

Silica is one of the most abundant minerals on earth, and exposure to silica dust has been identified as a risk factor for many SARDs, including SS, RA, SLE, and AAV .

Individuals working in agriculture, mills, drilling, painting, and textiles have been identified to have a greater risk of developing AAV disease .

Multiple case reports have shown that continuous exposure to silica increases the risk of positive ANCA.

Several studies have described cases of silica exposure and AAV.

Main and Wroe described three cases of silica-exposed patients with AAV, two of whom still required dialysis after treatment.

Analysis of the occupational histories of 16 patients with AAV revealed that patients with vasculitis were more likely to be exposed to silica than controls

Multiple case reports have shown that sustained exposure to silica in an occupational environment resulted in a significantly increased risk of ANCA positivity. A meta-analysis involving six case-control studies showed that silica exposure was positively associated with AAV incidence.

Studies have confirmed the dose-related effects of silica exposure. A meta-analysis showed that silica exposure was positively associated with AAV.