Danger Dust

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A community for those occupationally exposed to dusts, toxins, pollutants, hazardous materials or noxious environments

Dangerous Dusts , Fibres, Toxins, Pollutants, Occupational Hazards, Stonemasonry, Construction News and Environmental Issues

#Occupational Diseases

#Autoimmune Diseases

#Silicosis

#Cancer

#COPD

#Chronic Fatigue

#Hazardous Materials

#Kidney Disease

#Pneumoconiosis

#The Environment

#Pollutants

#Pesticides

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Bampot

Environmental factors influencing the risk of ANCA-associated vasculitis (www.ncbi.nlm.nih.gov)

submitted 7 months ago by Bampot to c/dangerdust

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Multiple case reports have shown that continuous exposure to silica increases the risk of positive ANCA.

Studies have confirmed the dose-related effects of silica exposure. A meta-analysis showed that silica exposure was positively associated with AAV. A case-control study suggested a 3.4-fold increased risk of ANCA serology positivity in individuals with occupational silica exposure.

Another study suggested that silica can induce the expression of MPO in the cell membrane of neutrophils and monocytes, causing ANCA-related autoimmune responses.

However, research on the relationship between sustained exposure to silica and severity of AAV remains inadequate.

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