The app I've been using (connect) has a manual filter via keywords, which might be along the lines of what you're looking for. I'm not sure if there's anything native that does it (yet) though.
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The problem with filtering by keyword is that it will inadvertently block content you might actually want to see. For example, “Free tacos one block north of football stadium,” or “Hockey player rescues truckload of adorable puppies”
OP mentioned looking for ways to block by certain words, which evidently face the same problem as filtering by keywords, either ways will have risks of catching unintentional topics or just missing them.
Not as of now, as far as I’m aware. You have to do it manually per instance, per magazine, and per user.
It took me a while but my /all is mostly free of the topics I don’t give two shits about. Every now and then I still have to whack-a-mole users and mags, but sadly that’s how it is.