I really don't care. I'm fine playing genderless shapes (and if PacMan didn't have "man" in his name nobody would even know he was a he) if the game is fun. Even when finishing the first Metroid back when I was a kid and discovering Samus was a woman didn't really blow my mind like it did for so many others.
The only time I care is when it actually matters in the game. Such as Fallout 2 and being able to skip fighting the Slavers to rescue Vic but only as a woman, or older FPS games where the smaller frame of a female model came with a smaller hitbox, or even Demon's Souls where male and females have different armor sets so my gender changes with my build.