this post was submitted on 02 Nov 2023
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Upvoted for the news that these treatments are speeding towards approval. However, the point that no one knows how these new treatments work seems silly, given my understanding that no one seems to know exactly how antidepressants in general work either (or at least they didn't until recently?), even ones that have been used for decades, like Prozac.
Here's a quote from an article from 2021: I've been making references on this blog for years about how we don't even know how antidepressants work
I mean, this is going to sound super-oversimplified but hopefully correct: we know that Tryptamines like LSD and psilocybin serve their most novel functions on 5-HT~2A~ serotonin binding sites and there are a lot in the thalamus, which is largely responsible for routing information to other parts of the brain. That would explain a lot of people's accounts of synesthesia.
The circumstances that are necessary to promote neuroplasticity weren't clear when I was in skool, but the fastest way to get a credible answer on the internet is to be wrong about something, so I'm going to claim it was 95.6% magic.
One of the requirements for Brannigan's law is that you can't make it obvious that you're invoking it.
Fuck.