SCP
scp-wiki.wikidot.com
Secure
The Foundation secures anomalies with the goal of preventing them from falling into the hands of civilian or rival agencies, through extensive observation and surveillance and by acting to intercept such anomalies at the earliest opportunity.
Contain
The Foundation contains anomalies with the goal of preventing their influence or effects from spreading, by either relocating, concealing, or dismantling such anomalies or by suppressing or preventing public dissemination of knowledge thereof.
Protect
The Foundation protects humanity from the effects of such anomalies as well as the anomalies themselves until such time that they are either fully understood or new theories of science can be devised based on their properties and behavior. The Foundation may also neutralize or destroy anomalies as an option of last resort, if they are determined to be too dangerous to be contained.
view the rest of the comments
Not sure if this is what you mean, but I just finished the first season of Dirk Gently's Holistic Detective Agency, which is filled with SCP themes. I highly recommend the show.
John Dies at the End is also great, although not really an SCP derivative.
Man, the first season of Dirk Gently's was amazing. The second is fine, but a long ways away from the heights of the first. Bummer it never continued, though I seem to remember the show runner did some inappropriate things...
Is the show based on the books or is it doing its own thing?
Pretty much doing it's own thing. Other than the titular character and the idea of "everything is connected", there's not much connection to the books.
AFAIR they are almost completely separate.