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2024-11-11

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Migraines linked to rare genetic variants that could boost treatments | New Scientist (www.newscientist.com)

submitted 1 year ago by [email protected] to c/science

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We know that migraines, which are recurrent and sometimes debilitating headaches, have some genetic basis, but the link with our DNA isn't entirely clear. Newly identified genetic variants could help in developing treatments, according to recent study.

Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura.

Journal reference:

Nature Genetics DOI: 10.1038/s41588-023-01538-0

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[–] wreckedcarzz 22 points 1 year ago (2 children)

I found the cause of my debilitating and almost-daily migraines for 15+ years, when I had a stroke that left me with numerous permanent disabilities.

I've talked to a couple friends who also suffer from similar ones and neither had been to a doctor recently. I now tell everyone to check their bp and for fucks sake see someone about it, don't just pop 2 pain pills and lay down. You may be relatively fine, but you don't want to turn into me. My life ended that day.

[–] esmevane 10 points 1 year ago

Ok! I’m convinced. Thanks for saying all this, really. I needed this reminder to bring the migraines up next time I see the doc.

[–] lwuy9v5 3 points 1 year ago (1 children)

Not trying to be shitty - just curious - a your doctors in those fifteen years never noticed high blood pressure? That sucks so much

[–] wreckedcarzz 1 points 1 year ago* (last edited 1 year ago)

My doc as a child/teen was, bluntly, pretty shit. They put me on progressively stronger and stronger pain meds without looking for the reason for my pain. And I was a kid, you figure doctor knows what they are doing (or gave a shit about their patients) so I didn't question it. By the time I was out of the children's doc, I'd grown very distrustful of the profession, so I got that sort of 'blanket effect' (one is bad so all are bad) and didn't see a doc again until the stroke.