Technology

Wealth inequality won't stop these discoveries making people's lives better, it will just ensure that the 1% live forever in perfect health and the 99% get to watch their kids and grandkids get sicker as the environment, living standards and employment situation deteriorate, until automation gets to a point where the working class are no longer required and can be safely left to starve or killed off.

"Red tape" eh? Shit if I had MS or AIDS I'd get some red contact lenses and some fake white fur, just don't ask where the rat tail is attached, and be in for clinical trials in the AM. "I'm a rat it's fine. I mean squeek squeek."

It's a clash between scientists needing to be optimistic about their findings to maintain funding and real people needing it asap. We need to fund more medical research outside of for-profit corporations and increasingly expensive academia

It’s like all the revolutionary battery technologies, computer storage technologies, fusion, cure for cancer, anything with graphene in it, cure for immune diseases and all that. People just love to write clickbait articles about this stuff.

Developing these ideas in the lab takes decades, and turning those ideas into actual products takes even more time. When you see articles about these topics, you can be pretty sure you’ll never hear about it again.

Edit: Just to be clear: technology is going forward all the time, but news articles tend to fucus on things that are interesting or fascianting, and extrapolate from there. The technologies that actually end up becoming widespread might not be interesting enough to write about.

I was thinking of forwarding this to a friend with type 1 and remember the tale of misery from the last one I sent. Exactly what you said. She’s 38. Don’t get her hopes up.

A few people asked for more information about these trials that I referred to above. In theory if you can cure one autoimmune disease you should be able to use the same method to cure any of them. Obviously we don't know that for certain and diseases like Diabetes has the extra step of inducing the growth of new beta cells to produce insulin (more on that below)

That said, the three trials I referred to are Celiac specific. I have this and T1D so those are the two I've been following most closely, but I definitely dive into news on ms or any of the other autoimmune diseases.

Note: all of these entered phase 2 this year. They are in the EARLY EARLY stages of that phase, so we should see results in 2025/26 for these. I am also ignoring any trial not in phase 2. Also note that several diabetes and ms cures are essentially variants of these, and many of them are running in parallel.

KAN-101: This is from Anokion and happens to have a trial in my area, hence it's the one I know the most about. This one works by targetting the liver where the relevant immune cells are produced. Even in their phase 1 trial they found that patients had a dose dependent reduction in IL-1 (a cytokine that your body releases in the presence of gluten if you're celiac). As with all these trials they need to determine what dose is needed to be a full cure and is it permanent?

TAK-101: This is an MS cure that was adapted for celiac disease, originally developed by ImmunisanT. They also have several other variants of this one, including T1D. Unfortunately their website seems to be down. Takeda is handling the clinical trials here and last I heard they're waiting for the celiac results before pushing forward with the others, but they expect them to move quickly at that point. Here's a video by one of the researchers behind this.

TPM502: I know the least about this one, it's from Topas Therapeutics and they recently announced the start of phase 2 trials in Finland, Norway, the Netherlands and Sweden. [more]

I should emphasize that there is no guarantee any of these treatments will work and everyone is tired of the latest "breathrough" that we never hear about again. Some of the trails above had to go back to the drawing board after hitting phase 2, TAK-101 is a newer generation of "Nexxvax" which if you google that you'll find articles about its cancellation.

Then Diabetes has the problem of beta cells needing to be restored or replaced. That's looking feasible either by transplanting adult cells, stimulating the growth of new ones using stem cells or a similar concept. One proposal hides the beta cells from your immune system entirely inside a scaffold. That last one is more of a new treatment than a cure, but it definitely beats what we have now.

The good news is that work IS being done in this area, progress is being made, and I know at least with KAN-101 they have demonstrated it showing results. The cure is coming. Even if most or all of these trails fails the fact that they've seen the results that they have is still really good news.

Again, it's coming. It's just not in a hurry.

The article has the link to the original paper published in Nature Biomedical engineering at the bottom.

https://www.nature.com/articles/s41551-023-01086-2

Honestly asking, why even bring this up? What does this have to do with the topic of the post?

All you do is start an argument and divert away from the topic that was supposed to be discussed.

People are saying it causes 5g.

This just got me and I needed a good laugh so thank you.

Going on my seventht day of COVID, getting worse, and my scumbag immune system has decided this isn't nearly as interesting as the large intestine and everything south of it that it took a few years back.

C'mon, little help here?!

The source of this post might be. But the study is solid as far as I can see. It was published in Nature Biomedical Engineering last week.

https://www.nature.com/articles/s41551-023-01086-2

As phase I clinical trials are underway, we'll see how far this can get. But sure, don't expect too much, then you won't be disappointed. Let's hope it can really help people.

That's the holy grail for this type of research. Autoimmune cures are seen as a stepping stone for that