An immutable distro, to my understanding, locks core components of Linux (mainly /sys afaik) from interaction from not only bad actors but also the user so that you can't fuck up you're system in a way like Linus from LTT (removing X11 by forcefully ignoring all warnings). Applications can be installed as Flatpak, AppImage, Snap or through OverlayFS from regular repositories.
Advantages to (non- tech savvy) users are an additional layer against their own mistakes and easier support since the important stuff is identical on every install of the given distro.