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Cancer vaccine with minimal side effects nearing Phase 3 clinical trials (abcnews.go.com)

submitted 5 months ago* (last edited 5 months ago) by MicroWave to c/news

16 comments fedilink hide all child comments

Each shot would be completely personalized to the patient.

...

Wagner's TLPO cancer vaccine has been tested in hundreds of patients with advanced forms of melanoma in Phase 2 clinical trials.

The most recent data presented at an academic conference showed nearly 95% of people given only the vaccine were still alive three years after starting treatment and 64% were still disease-free. Among the most advanced forms of melanoma, disease-free survival after three years for people with stage III disease was 60% in the vaccine-only group, compared to about 39% in the placebo group. Disease-free survival for those with stage IV disease was about 68% in the vaccine-only group, and zero in the placebo group.

The most common side effects were redness or pain at the injection site, fever and fatigue after the injection – similar to other vaccines that stimulate an immune response.

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[–] TardisBeaker 18 points 5 months ago* (last edited 5 months ago)

A lot of times they don't do placebo once the trial gets to that stage. My dad with cancer was a treatment guinea pig & one of the study stipulations was that they wouldn't get placebo. Too cruel to get their hopes up. ETA: I know this one states it had placebo group. And I understand the reason for it, obviously. Just saying my dad's experience was they promised no placebo group bc it was so late stage in testing.