this post was submitted on 12 Nov 2024
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It does make more sense if you consider that it is part of a line of Hedgehog genes, all of which make Fruit fly embryos look like hedgehogs (spiky) if they're inactivated.
They didn't just go "Let's name a gene with bad outcomes if mutant in humans after a video game character! Yipee! Hooray!", at least not for that.
Though they did name SHH's inhibitor Robotnikin.
Oh I get how it got that way, it's just unfortunate what that lead to in a clinical setting.