I haven't seen Arcane, but tweaking the setting should be relatively straightforward.
The key thing about Doskvol that I'd recommend carrying over is the pressure cooker environment you get from having a place that the crew can't easily or meaningfully leave. It allows the tension and stakes to naturally ratchet up over time, forcing the crew to deal with the problems they create rather than laying low until things blow over.
Aside from that, ghosts and the occult could get narrative makeovers to better suit your setting.
I think you should go for it!
I have an Ender 3 V2 that I barely ever print on any more because I have a RatRig V-Minion now. I love this little monster, it's so fast.