Ooooh, dethrone Skyrim? I dunno about that. I love Night City and I can't get enough of this world, but this is a very finite game. It's not all that moddable so it lacks the same scale of replayability as Skyrim. Of course, it's also a decade newer so it's got that going for it.
I think Cyberpunk is in a state where, if it was released today, people would have praised it like the next Witcher 3. Clearly not all things to all people, but the remaining bugs are tolerable and the world is both beautiful and fascinating.
I'm afraid CP2077 is never going to reach Skyrim levels of "Moddability". Bethesda games are built from the ground up with modding in mind, and the tools Bethesda puts out for modders are far superior than what CDPR has done, to date. Maybe that'll change when they move to UE5, but as for this engine, unless they dramatically upgrade the Wolven Kit despite moving on from the game, we're never going to see much more than more of what we've already seen.