PlanetMedicines

American Society of Ketamine Physicians, Psychotherapists & Practitioners — this one just added the Psychotherapists and Practitioners part recently, and is highly biased towards MD level clinicians only. Worth $300 per year membership? (Not for me in the year I was.)

American Psychedelic Practitioner Association — this one is new, like much of the psychedelic ecosystem. They do have the support of CIIS and Soundmind faculty and have just released clinical guidelines for psychedelic practice that emphasizes psychotherapy. They do have a member forum and are looking for folks to get involved in different workgroups. I joined, and am waiting to see how they evolve.

Psychedelic Medicine Association I joined, they do have a forum that no one uses, and haven’t seen much benefit or evolution so far.

American Association of Psychedelics — just found this one today, and have never heard of it. Looks expensive, and not sure what their certification means from them at this point in the ecosystem/infrastructure.

Mystical experiences are characterised by ineffability – that is, what is subjectively experienced is difficult, or impossible, to adequately put into words. However, we can go a step further and say that such experiences are transrational: their ineffability relates to the fact that these experiences lie outside the scope of reason. >

cross-posted from: https://lemmy.world/post/11373547

This study found that a single, open-label administration of psilocybin 25 mg led to an acceptable experience for participants with TRD when administrated adjunct to an SSRI and supports further development of psilocybin with psychological support for people with TRD. This study demonstrated the feasibility of simultaneous psilocybin administration to multiple participants as previously reported [1, 52], provided that adequate support is available. This design could reduce resource requirements for administration and provide a more accessible option for future research or in clinical practice. These encouraging results suggest that further investigation of psilocybin adjunct to antidepressant drugs would be valuable, especially in cases where antidepressant drug withdrawal may not be desirable.>

This study found that a single, open-label administration of psilocybin 25 mg led to an acceptable experience for participants with TRD when administrated adjunct to an SSRI and supports further development of psilocybin with psychological support for people with TRD. This study demonstrated the feasibility of simultaneous psilocybin administration to multiple participants as previously reported [1, 52], provided that adequate support is available. This design could reduce resource requirements for administration and provide a more accessible option for future research or in clinical practice. These encouraging results suggest that further investigation of psilocybin adjunct to antidepressant drugs would be valuable, especially in cases where antidepressant drug withdrawal may not be desirable.>

Patients who received daily oral ketamine experienced a robust antidepressant and anxiolytic response with few adverse events. The response rate for depression is similar to those found with IV ketamine; however, the time to response is more protracted. The findings of the potential efficacy of oral ketamine for depression and the response of anxiety symptoms are novel. Further investigation with randomized, controlled clinical trials is necessary to firmly establish the efficacy and safety of oral ketamine for the treatment of depression and anxiety in patients receiving hospice care or other subject populations. >

24 trials representing 1877 participants were pooled. Racemic ketamine relative to esketamine demonstrated greater overall response (RR = 3.01 vs. RR = 1.38) and remission rates (RR = 3.70 vs. RR = 1.47), as well as lower dropouts (RR = 0.76 vs. RR = 1.37). Conclusions: Intravenous ketamine appears to be more efficacious than intranasal esketamine for the treatment of depression. >

Ketamine and esketamine are effective, safe, and acceptable treatments for individuals living with depression. >

The therapeutic effects of psychedelics appear to depend on psychological processes that are evoked by synergies between these substances' pharmacological action and the context in which they are administered. To better understand and further develop psychedelic therapy, theoretical models that specify these processes are needed. Here, we took a CBT perspective and proposed such a model based on Carhart-Harris and Friston's (14) relaxed-beliefs account of psychedelics' acute brain action: When combined with specific context factors that are typically present in psychedelic therapy, belief relaxation can increase motivation for acceptance via operant conditioning, thus engendering episodes of relatively avoidance-free exposure to greatly intensified private events. Under these unique learning conditions, relaxed avoidance-related beliefs can be exposed to corrective experiences and become revised accordingly, potentially leading to long-term increases in acceptance and associated reductions in psychopathology. This model shows substantial parallels between psychedelic therapy and CBT that may be harnessed by using CBT as a therapeutic framework for psychedelic interventions. Empirical research is needed to validate and further develop the proposed model and, more generally, to examine the relative importance of acceptance as a mechanism of action in psychedelic therapy. Therefore, appropriate instruments for measuring processes related to avoidance and acceptance in psychedelic states must be developed. Although still requiring further empirical support, the proposed model demonstrates the usefulness of the relaxed-beliefs account as a basis for building theories of the therapeutic effects of psychedelic drugs.>>

The present paper critically reviews the models of PAT framing to provide a comprehensive picture of current practices in clinical psychedelic research. While some structural aspects of PAT seem to recur in clinical studies, the therapeutic stance and theoretical frameworks seem far from being exhaustively defined. Considering that psychedelics seem to enhance sensitivity to the internal and external environment (i.e., suggestibility), future research should provide more details on how such environments are constructed in terms of suggestions, description of the mechanisms underlying conditions and treatments, setting of expectations, therapeutic models employed and quality of the therapeutic relationship. This review fills a gap in the current literature and provides a systematic way to think about psychotherapeutic framing of PAT. The concepts discussed above are relevant to future construction of studies, designing of training programs for aspiring psychedelic psychotherapists and are presented with the intention to contribute to the development and implementation of PAT in several fields of psychiatric, psychological and medical relevance.