Therapeutic Ketamine

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Discussion of prescription ketamine for pain and mental health indications.

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submitted 2 months ago* (last edited 2 months ago) by PlanetMedicines to c/therapeutic_ketamine
 
 

Ketamine’s Role in Spirituality: How One Synthetic Drug Catalyzes a Natural Experience (Woods, 2021) compares the spiritual experiences reported in magic mushroom ingestion, psilocybin research, and the generic medicine currently available worldwide, ketamine.

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submitted 5 months ago* (last edited 1 week ago) by PlanetMedicines to c/therapeutic_ketamine
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“ Discussion: This work adds to the growing body of evidence that under the supervision of a pain specialist, oral ketamine therapy may be a safe, tolerable and effective treatment for chronic pain conditions which have not responded to other management options. Further research is required to produce a more accurate understanding of its chronic use.

Key message: This real-world study shows that patients being treated with oral ketamine for chronic pain report decreased severity of pain, improved mood and increased quality of life across all conditions.”

Note- this study included patients taking ketamine by mouth for up to 12 years.

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This paper presents a valuable investigation of the acute effects of ketamine in healthy volunteers using rating scale-based behavioral and resting-state fMRI-based neural measures. It provides solid evidence of inter-individual variability in responses to ketamine along with associations to relevant gene expression markers (somatostatin, parvalbumin) in the brain. >

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