Guix
Ah yeah, I'm in the same situation. My daily driver is arch, but at some point I came across guix and installed it on an old laptop for when I feel like computering in front of the tv or something. Somehow I've even gotten yubi keys to be recognized and usable, but I really feel like someone needs to write an intro to the system-level APIs. The official documentation often feels like it assumes a lot more understanding of this than I do, and I haven't figured out a way to wrap my head around it.
Since it's not mission critical for me though, it's been a fun experience!
...if it were you, it would be twerrific!