I used the starting loadout for a good few missions. I haven't saved any loadouts, I just keep the frame balanced in weight/HP, and switch out the guns to counter shit I run into.
Really liking the OS Upgrade that lets me carry more normal guns instead of shoulder mounted stuff. Right now I'm running the 10 missile pod on the left, and extra laser rifle hand weapon on the right.
And then double gatlin to just delete enemy HP close up.