I'm hoping to hear more about what Obsidian has been working on. Microsoft has a lot of studios, so hopefully we get more details on their mystery projects. Starfield should be exciting to see at the very least.
There's a non-zero chance that we will see more Silksong, so here's my prediction. Todd Howard hits us with a one more thing at the end and the conference ends with a Silksong release date. Playable inside of Starfield. Watch for it.