When I was on antipsychotics (olanzapine, quetiapine, aripiprazole) I found that it blunted the high significantly. There's lots of other people who feel the same and I see it as a common complaint against that class of medication online.
Also, atypical antipsychotics are usually really effective trip killers. They tend to fuck with highs with a lot of drug interactions, so a lot of other drugs might not work the same.