There was an Independent drug store in our community. They couldn't compete on price with all the mega chains in the area, including three grocery stores and a target cvs. And yet, they remained open for years, because the community knew that the pharmacist was also a drug dealer selling pills.
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Many large HMOs basically require mail order prescriptions now. I have heard many complaints because of how unpredictable USPS can be and strict limits on dispensing, ie last pill of month and mail is late.