Something like this happened to my Logitech mouse. I had my settings saved to the onboard memory. Once I deleted and re-saved the profile onboard, it worked again. Maybe worth trying.
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I have had many mouses. Most of them broke the side buttons. The scroll wheel usually lasts as much as the side buttons. After that. The left/right main buttons fail.
I have never had a mouse with a broken sensor though. I would look for solutions in the software (calibration and settings). But it's not impossible that it's broken.
I'd look for dust or schmutz on the sensor
Does Synapse have different sensitivity setting for different axis?
Yes, some versions apparently do. I don't know if that your issue but give it a try.
Good idea, but that doesn't appear to be it either.
Haven’t heard of that before, although I will state I’ve never had a mouse die on me (only been PC gaming for under 10 years). Do you have another machine to test it on?
Same problem on another machine. It seems so strange that I've had this happen before with a different brand, and that the vertical works normally.
This mouse is probably 4 years old fwiw.