No, because you don't change the fundamental harmonic imbalance, just change it's location in the cycle.
A large center cylinder would/could solve the rotating mass imbalance of a 3 cylinder. You trade it instead for a huge airflow, combustion, and power output imbalance that would be incredibly difficult to engineer out for a good running engine. The center cylinder will develop much more torque, take longer to burn fuel, get hotter, and result in a lopey torque application that bodes badly for bearing and crankshaft life.