Every time I gaze upon the night sky, I always look for the Pleiades. When I was very young, it was the first thing that I had questioned when looking at the stars. It was faint, but I could see it. I had no idea what I was looking at, or if anyone knew what it was. It was difficult to research as a young child in the early 90's, but I was determined to find out, and it began the lifelong love I have for space to this day.
Cassiopeia - i read somewhere as a kid (no idea where) that from Proxima Centauri, the Sun would appear as an extra zig in the zigzag and was immediately obsessed. It's also really easy to find as a big 'W' in the sky.