science

All basic science comes with limitations, just like human clinical trials (heterogeneity and limited scope of control, let's not even talk about observational). But I don't think it's of very little use. I'm just talking generally, I didn't go through the paper thoroughly to give a technical comment, but if a treatment exacerbates a pre-existing condition or triggers a condition in an at-risk model, I'd think it can be quite useful because such circumstances do occur plenty in humans.