this post was submitted on 29 Sep 2023
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I thought it was just (or mostly) partial pressure of O2 when it comes to hemoglobin? It's been about 15 years since I was in school so I might remember wrong.
"Carbon dioxide increases hydrogen ion concentration and lowers tissue pH. As a consequence, hemoglobin’s affinity for oxygen decreases and oxygen release to tissues is facilitated."
https://www.medmastery.com/guides/blood-gas-analysis-clinical-guide/what-factors-affect-hemoglobins-oxygen-affinity