I remember when I first saw Graham. I was so excited that I immediately homebrewed him into my D&D campaign as a playable human subrace. I felt so hopeful that one day we could genetically engineer ourselves into something as cool as Graham.
I don't think this was the intended reaction.
There's all kinds of mutated body horror creatures in ttrpg's it's not that weird.
I'm working on a half-slug half-man adventure module for instance.