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As many as 1 in 5 people won't lose weight with GLP-1 drugs, experts say (apnews.com)

submitted 1 month ago by MicroWave to c/health

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Summary

As many as 1 in 5 patients may not lose significant weight with GLP-1 drugs like Wegovy and Ozempic, despite their popularity and effectiveness in clinical trials.

Experts attribute this variability to genetic, hormonal, and brain-based differences in regulating energy, as well as factors like sleep apnea or medications that hinder weight loss.

Non-responders often face frustration, but doctors stress alternative options, including different medications, lifestyle adjustments, or older treatments.

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[–] [email protected] 8 points 1 month ago

To be honest, 80% effectiveness for a generation 2 of a long term drug is a pretty nice value, especially in this field and the regulatory mechanisms it affects.

That's better than basically most psychiatric, antivirals, antihypertensive and antidiabetic medication.

Only a few long term drugs like contraceptives, some chemotherapeutics and some hormone replacement drugs work that well in that many cases. And most of them are not Gen 2 drugs in a new field.