Awww that's really too bad, but thanks for letting me know. What I would do to get some of the old Nokia phones with modern specs...
TheDuffmaster
joined 2 years ago
What's the phone in the thumbnail? Don't see it in the article, but reminds me of the symbian os Nokia e7. One of the best phones I ever owned.
Paper Summary
Methodology The researchers investigated a specific ribosome variant in Bacillus subtilis bacteria that offers resistance to certain antibiotics but might come at a physiological cost. They focused on the role of magnesium ions (Mg²⁺), essential for ribosome stability and cellular energy storage. The team used a mix of lab experiments, computational modeling, and bioluminescence assays. Bacterial strains with and without the ribosome mutation were grown under different magnesium levels and exposed to antibiotics to see how they performed. They also measured magnesium and ATP (cellular energy) levels to uncover how the mutation impacts bacterial physiology.
Key Results The study showed that bacteria with the antibiotic-resistant ribosome mutation (L22*) had a harder time surviving when magnesium was scarce. Although the mutation helped bacteria resist antibiotics, it caused them to soak up too much magnesium, leaving less for other vital processes like producing energy (ATP). This made the mutated bacteria weaker in low-magnesium environments compared to normal bacteria. However, when magnesium levels were high, the mutated bacteria thrived under antibiotic pressure.
Study Limitations The experiments were conducted in controlled lab conditions, which might not perfectly mimic real-world environments. The study focused on a single ribosome mutation in one bacterial species, so the findings might not apply universally. The computational models used make assumptions that may not fully capture all biological complexities.
Discussion & Takeaways This research highlights a trade-off: the ribosome mutation provides antibiotic resistance but makes bacteria more dependent on magnesium. This creates a potential vulnerability — targeting magnesium availability might help control antibiotic-resistant bacteria. The study also sheds light on the broader role of magnesium in linking ribosome function and energy production, suggesting new strategies to combat resistance by exploiting these biological connections.
Funding & Disclosures This study was supported by a diverse range of funding sources, reflecting its interdisciplinary and international nature. The National Institute of General Medical Sciences provided grant R35 GM139645 to support foundational research efforts by Gürol Süel. The Army Research Office funded critical components of the work under grants W911NF-22-1-0107 and W911NF-1-0361 (G.M.S.), while additional funding was provided by the Bill & Melinda Gates Foundation (INV-067331, G.M.S.).
Contributions from study author Jordi Garcia-Ojalvo were supported by the Spanish Ministry of Science, Innovation and Universities and FEDER projects PID2021-127311NB-I00 and CEX2018-000792-M, as well as the Generalitat de Catalunya’s ICREA Academia program. Researcher S. Banu Ozkan received support from the National Science Foundation Division of Molecular and Cellular Biosciences (award 1715591) and the Gordon and Betty Moore Foundation. The authors have declared no competing interests, ensuring the integrity and impartiality of the research.
Have a friend who worked it, he said the same thing.
Looks like a caricature of Jack Nicholson
Didn't pre-stroke Fetterman win in PA? Often he was compared to Bernie, although maybe the media got that one wrong considering what stances Fetterman leans on these days.
Seriously
The candidate that adapts universal healthcare and figures out how to sell it to the masses will save progressivism, simple as that. Liberals will never win unless they come with that kind of change and clear economic benefit to the average citizen.
Yeah there will definitely never be a movie like that again
I need to listen to most Queens of the Stone Age, didn't know they got this heavy.
Looks like the bottom one is the top one with the outer layer of posters ripped off, interesting