You can do this using Lutris.
- Install it from Flathub
- Open Lutris and have it install the tools it needs (wine, dxvk, etc)
- Close Lutris
- Use Flatseal to limit its permissions; remove network, filesystem access, etc
- Open Lutris and run the game
Note that this isn't a perfect sandbox. For example, the game can still send a link to your browser to open. Theoretically it could do something malicious with that. Though you could probably work around that issue by changing your default browser to a flatpak version and disable network access there. There might be other small sandbox breaks, but nothing I can think of.