I upgraded the RAM of my RS1222 to 32GB shortly after I bought it. I ordered memory with pretty much identical timings like the original ones from Synology with the max compatible capacity and it worked fine for me.
I wanted to tell you this so you can probably save some money, even if nobody has experience with your model. Only downside for me were notifications on every boot that non original RAM was detected. Other than that everything works fine for two years now.