X4 foundations and relevant DLC. I have multiple saves with over a year worth of playtime
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I put multiple thousand hours into Mount blade warband, Crusader Kings 2, Europa universalis 4, and more.
Factorio and RimWorld immediately come to mind. Even with the base unmodified game, you’ll likely get several weeks of gameplay out of Factorio. Then if you dive into modding, you’ll never put it down. Multiplayer is really nice too. And their big DLC just got announced, and is planned to drop in a few months. So now would actually be a great time to dive in, because you’ll get access to the DLC about the same time that you’ve burned through the content on the base game.
I don't know how much is truly infinitely replayable outside of tetris, but for what it's worth I have 250 hours into dead cells and I still haven't beaten 5 cells or even reached the final biome. You'll definitely get replay value out of it, the game is fantastic.
Honestly, Skyrim. With so many great mods available these days, you can literally turn it into a whole different game. And with modpacks on Nexus, Wabbajack or similar sites, it's easier than ever. I'm just getting back into it myself after 3 years, but I'm still a big fan of getting into the nitty gritty of it and configuring everything myself.
Football Manager 2016 was the first version I tried. I put 1,500+ hours into it and only stopped because I decided to upgrade to Football Manager 2018. I'm on 2024 now at ~400 hours.
Heroes of Might and Magic - the originals. Mostly 3, but any from 1 to 5 can do it.
6 and upwards, it's just pure Ubisoft enshitification. Can't even play them properly anymore due to the online component having shutdown its service.
I have enjoyed caves of qud. Feels like every run is brand new.
Just Cause 3, with the additional DLC. I've been through all of it three full times, slowly plugging through a fourth (when time allows)
I was about to suggest "Balatro" but you don't want infinite dopamine game then play The Binding of Isaac:Rebirth.
I’ve played Risk of Rain 2 on and off for years and I’m not bored of it yet
I want to throw out Mario Bro 3, Tetris, Dr Mario, and Sonic Mania. Just pick up and go, no long term commitment, always fun solo but you can add a friend anytime. Simple but rewarding game play loop.
For me, that would be the 3D Mario games (or any Mario game, really).
I have over 70 hours logged into Super Mario 3D-Stars, and that’s just the newer way I’ve played these games.
Red Dead Redemption 2, Fallout 4, the BioShock series
Besides what people have mentioned, you also have simulator type games like SimCity. Though with SimCity, I got bored of the "new" SimCity they released.... in 2013. Either play something like SimCity 4000, or try Cities Skylines.