Presumably there would be places on the outskirts where you would see the telltale gamma-ray signature of annihilation. No idea if the flux would be sufficient to observe, but I imagine a stacking analysis would see it.
this post was submitted on 10 Jun 2024
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Would the flux would be sufficient? Galaxies are huge, but intergalactic space is also very empty.
My understanding is that antimatter "looks" just like matter. https://www.sciencealert.com/physicists-have-observed-the-light-spectrum-of-antimatter-for-first-time