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What are your hidden gem medications/drugs/substances and what makes them ideal for your usecase (self.asklemmy)

submitted 1 year ago* (last edited 11 months ago) by cheese_greater to c/[email protected]

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If you notice an improperly formatted reply, kindly message the poster and gently remind them it needs to comport with the Naltrexone example below. It is simple and keeps things traversable and useful, thanks 🙏

Naltrexone

I will start with naltrexone, which can help people who have difficulty regulating their drinking have a more natural and sustainable relationship with alcohol should they choose to not cut it out of their lives entirely.

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[–] cheese_greater 0 points 11 months ago (1 children)

Yep, this seems to the magic number; I shudder when I hear people taking like 5-10mg. How can that be safe unless most of it is destroyed via digestion

[–] [email protected] 3 points 11 months ago (1 children)

Since it's a natural hormone the body already has ways to get rid of it. It has a half-life of less than an hour. The lethal dose is so high we haven't been able to intentionally kill animals with it: "Melatonin is not fatal even at a dose of 800 mg/kg in animal studies".

The big risk of ongoing high doses is becoming so dependent on it that you wake up as soon as it wears off (e.g. after only 4 hours of sleep). At this level you basically can't sleep without it and have to slowly wean yourself off to get back to normality.

[–] cheese_greater 1 points 11 months ago

I found my dreams were extremely vivid and often extra-disturbing when my dose was high to the extent Im implying. Also, because it was so vivid and palpable, I just didnt feel rested cuz I was so engaged/engrossed by it