I have a separate PC for VR (with an old Vega64 in it) on my valve index. Just a week or two ago I got fed up with something on Windows 10 (i think it was trying to get me to upgrade to windows 11 maybe?) and installed bazzite.

I started with HORRIBLE performance issues. Like could barely run beat saber smoothly issues. And then I changed something minor around (Disabling the VR Home was I think the biggest thing, it's like it was constantly running in the background or something), and ran some script i found online (https://gist.github.com/galister/a85135f4a3aca5208ba4091069ab2222 - i think it was this one, but disclaimer, i have not looked deeply at what this does, I was running this on a fresh gaming only distro so I had nothing to lose), and suddenly performance was just fine. I'm sure this isn't motion smoothing, but going from stuttery to smooth made me think of this. And a Vega64 is pretty old, and pre-dates any modern "rdna" AMD improvements. But it is GCN at least. I might

Audio switching on Bazzite does work. In fact it works more reliably than it did on windows for me. I feel like "using a gaming dedicated distro" can go a long way in making gaming things work, and this is a dedicated gaming PC. YMMV

Base station auto sleep mode does not work, but https://github.com/ShayBox/Lighthouse this CLI script can solve that. Just set something to run lighthouse --state on and lighthouse --state standby and you're good.

Performance is generally worse than windows, and some things won't work (OVR toolkit requires some windows specific things, so naturally doesnt work). But on windows, the first time i launch steamvr for any session (its not just per boot, its just more like "if the headset has been off for more than an hour"), the headset screen wouldnt turn on. Put the headset on, i can see the tracking is working via the mirroring on the display, but the headset doesnt light up. "Restart headset" and then it works. Every time. Doesn't happen on linux. And with bazzite, the power button does a quick sleep just like on a steam deck, and the index still works reliably after the computer wakes from sleep.

I don't do a lot of VR, i just regularly play beat saber for exercise. And it works well for that. I'm perfectly happy sticking with bazzite for VR workouts. I havent really tried any other games, but would be willing to test drive anything for compatibility if anyone cares about something specific.