Brief Summary: Sam and Dean are two brothers who witnessed their mothers horrible violent death via some sort of supernatural event. Later in life, Sam manages to escape the life of hunting monsters that his father raised him in, attending college. Dean shows up at his brother's college doorstep telling him that their dad is missing. Following clues from a weird voicemail left by their father, they go to a small town and find a "woman in white" who is a vengeful ghost that targets Sam and that they have to terminate.
Thoughts:
It's by no means a strong start to this series, having weak cinematography, Jared and Jensen haven't settled into their characters yet. The woman in white is called back to in the final season as well, which is a nice touchstone. From the very beginning, however, you see the brothers relationship that plays out over the next 15 seasons, in this very first episode.