I usually keep mutation potions for when I get threatening mutations from malmutating monsters. They will often remove some bad mutations while giving you a positive one or two. Bad mutations like weakness, dopiness, clumsiness, or even deformed (if you have good armor skill) can often be ignored, but ones that restrict your ability to use scrolls and potions are more threatening.
If survivability is a problem, it helps to equip a shield and start training shields, dodging, and armor to like 10-15, and maybe go higher once you are in Vaults.
Also, increase intelligence, getting it reduced to 0 will give you some nasty permanent debuffs until you get back above 0. 8 is usually enough for all game.
I am glad I don't have much attachment to websites. I think my reason for using this site is because I always try to use free stuff and would feel embarrassed if I started using something that wasn't as free without paying for it myself. For example, I play free/open source games like dungeon crawl and dwarf fortress, and I also like to play cogmind since I bought it. Using reddit's standard applications for free while other people who used different interfaces have to pay for it makes me feel like I'm being unfair. Anyways, there are many other places where I can look at furry art and I already rarely use these forum sites.