Not exactly programmatic, but I saw another streamer hook up their chat to super collider so folks could do a collaborative jam session. It was chaos, but a lot of fun.
(and for anyone not familiar with supercollider: https://supercollider.github.io/ - it's open source software that's "A platform for audio synthesis and algorithmic composition, used by musicians, artists and researchers working with sound.")
I'm not entirely sure about this meme in terms of the overt sexism. Looked it up a little and there's some talk about it, but hopefully it's not past the line of problematic. I have a hard time telling.