I've done a few Angels/Bobs runs in the past. While the added complexity of Angel's Petrochem provides a lot of complexity, it doesn't really add a lot of challenge. It's mostly just a chore.
My favourite for my last 2 playthroughs has been Krastorio 2 + Rampant, really focus a lot more on defense and fighting your way to resources.
SE and py scare me, don't think i'll ever touch those lmao.
Insanely excited for this... Hopefully my rig will be able to run it properly. And i hope the technical foundation of the game is a bit more solid than the original. As much as i love it, it does suffer from serious perfomance issues when you get to bigger cities, even on rigs built years after release..